Trump and Biden will not shake hands in next week's first debate in Ohio due to the Covid-19 pandemic.

The move is one of a number of adjustments that the campaign of President Donald Trump and Democratic candidate Joe Biden is making to comply with guidelines on social disparity, the source understands the matter on September 26.

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US President Donald Trump (right) and Democratic presidential candidate Joe Biden Photo: AP

Trump, Biden and debate lead Chris Wallace are reportedly not going to wear a mask.

The event took place on the campus of Case Western Reserve University and Cleveland Hospital in Ohio on September 29 for an hour and a half.

Unlike traditional presidential debate, there will be no post-election interview of the candidate.

During the Democratic preliminary debate in March, when the pandemic began to hit the US, Biden and Sen. Bernie Sanders entered a Washington debate without an audience and stood close apart.

The Covid-19 pandemic continued to affect the lives of Americans when cases in the world's largest epidemic area exceeded 7.2 million, of which more than 209,000 people died.